Under the hood, the Quattroporte offers a pair of engines, both of them fitted with twin turbochargers. The base engine, which comes on the Quattroporte S Q4, is a 3.0-liter V-6, its turbo helping to generate 410 horsepower and launch it to 60 mph in about five seconds. Top speed with the V-6 is 177 mph. A 3.8-liter twin-turbo V-8 is also available, the province of the GTS model, rated at 530 horsepower and 479 pound-feet of torque, or up to 530 pound-feet during the momentary "over boost" function. The result is 0–60 mph acceleration runs of 4.7 seconds and a top speed of 191 mph.

A ZF eight-speed automatic transmission is standard on both models. The V-8 GTS features rear-wheel drive, while the S has Maserati's Q4 all-wheel-drive system. The system is rear-biased, sending 100 percent of torque to the rear axle under normal conditions, and up to 50 percent to the front wheels when it detects slip. It adds little weight while making the car a bit more manageable in anything outside of ideal, dry-road conditions.

On the gas mileage front, the 3.8-liter V-8 in the GTS earns an EPA rating of 13 mpg city, 22 mpg highway, and 16 mpg combined, meaning it's not very efficient, even for a large and powerful luxury sedan. The all-wheel-drive S Q4 and its twin-turbo V-6 do slightly better, with ratings of 15/24 mpg, or 18 overall.